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Ausgabe
47
Aspirin-Allergie: Die Diagnose einer Allergie gegen Aspirin (ASS), oder
gegen ein
anderes Medikament aus der Gruppe der sog. nichtsteroidalen
Antiphlogistika, muss auch in Zukunft weiter mit Hilfe von
Provokationstests mit der entsprechenden Substanz gestellt
werden. Andere diagnostische Methoden liefern bisher keine
zuverlässigen Ergebnisse.
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Aspirin and other
nonsteroidal anti-inflammatory drugs (NSAIDs) are among
the most common causes of adverse drug reactions.
Majority of them are of the hypersensitivity type. The
two frequent clinical presentations of aspirin
hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis
(AIA/R) and aspirin-induced urticaria/angioedema (AIU).
The decisive diagnosis is based on provocation tests
with aspirin, as the in vitro test does not hold
diagnostic value as yet. Detailed protocols of oral,
bronchial and nasal aspirin provocation tests are
presented. Indications, contraindications for the tests,
the rules of drug withdrawal and equipment are reviewed.
Patient supervision and interpretations of the tests are
proposed.
Allergy
Volume 62 Issue 10 Page 1111-1118,
October 2007
To cite this article: E.
Niżankowska-Mogilnicka, G. Bochenek, L. Mastalerz, M.
Świerczyńska, C. Picado, G. Scadding, M. L. Kowalski, M.
Setkowicz, J. Ring, K. Brockow, C. Bachert, S. Wöhrl, B.
Dahlén, A. Szczeklik (2007)
EAACI/GA2LEN guideline: aspirin provocation tests for
diagnosis of aspirin hypersensitivity
Allergy 62 (10), 1111–1118.
doi:10.1111/j.1398-9995.2007.01409.x
EAACI/GA2LEN guideline: aspirin
provocation tests for diagnosis of aspirin hypersensitivity
- E. Niżankowska-Mogilnicka11Department
of Medicine, Jagiellonian University School of Medicine,
Krakow, Poland,
- G. Bochenek11Department
of Medicine, Jagiellonian University School of Medicine,
Krakow, Poland,
- L. Mastalerz11Department
of Medicine, Jagiellonian University School of Medicine,
Krakow, Poland,
- M. Świerczyńska11Department
of Medicine, Jagiellonian University School of Medicine,
Krakow, Poland,
- C. Picado22Servei
de Pneumologia i Allergia Respiratora, University of
Barcelona, Barcelona, Spain,
- G. Scadding33Royal
National Throat, Nose and Ear Hospital, London, UK,
- M. L. Kowalski44Department
of Clinical Immunology and Allergy, Medical University,
Lodz, Poland,
- M. Setkowicz11Department
of Medicine, Jagiellonian University School of Medicine,
Krakow, Poland,
- J. Ring55Department
of Dermatology and Allergy Biederstein, Technical
University of Munich, Munich, Germany,
- K. Brockow55Department
of Dermatology and Allergy Biederstein, Technical
University of Munich, Munich, Germany,
- C. Bachert66Department
of Otorhinolaryngology, Ghent University, Belgium,
- S. Wöhrl77Department
of Dermatology, Medical University of Vienna, Austria,
- B. Dahlén88Centre
for Allergy Research at Karolinska Institutet,
Stockholm, Sweden,
- A. Szczeklik11Department
of Medicine, Jagiellonian University School of Medicine,
Krakow, Poland
-
1Department
of Medicine, Jagiellonian University School of
Medicine, Krakow, Poland;
2Servei de Pneumologia i Allergia Respiratora,
University of Barcelona, Barcelona, Spain;
3Royal National Throat,
Nose and Ear Hospital, London, UK;
4Department of Clinical
Immunology and Allergy, Medical University, Lodz,
Poland; 5Department
of Dermatology and Allergy Biederstein, Technical
University of Munich, Munich, Germany;
6Department of
Otorhinolaryngology, Ghent University, Belgium;
7Department of Dermatology,
Medical University of Vienna, Austria;
8Centre for
Allergy Research at Karolinska Institutet,
Stockholm, Sweden
Andrew Szczeklik, MD, PhD
Department of Medicine
Jagiellonian University School of Medicine
8 Skawinska Str.
31-066 Cracow
Poland
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